Department of Physiology
28 Medical Drive, Centre for Life Sciences, Level 3, Singapore 117456
Tel: 6516 7773
Major Research Interests
Our group works on the cytokine receptor CD137. We investigate their function in myeloid cell development, immune regulation and in diseases such as Leukemia, Lymphoma, Rheumatoid arthritis and Systemic lupus erythematosus using in vitro experiments, animal models and patient tissues. Several of our projects aim at improving existing immunotherapy approaches and on developing novel ones.
- Myeloid cells
Rajendran Sakthi, Weng Tong Ho and Herbert Schwarz. CD137 signaling in Hodgkin and Reed-Sternberg cell lines induces IL-13 secretion, immune deviation and enhanced growth. OncoImmunology, In press, 2016.
Zhe Shao, Harfuddin Zulkarnain, Wan Lu Pang, Emily Nickles, Liang Kai Koh, Herbert Schwarz. Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APC leading to reduced T cell costimulation. J. Leukocyte Biology, In press, 2015.
Dharmadhikari Bhushan, Meihui Wu, Nur Sharalyn Bte Abdullah, Sakthi Rajendran, Nur Diana Ishak, Emily Nickles, Zulkarnain Harfuddin, and Herbert Schwarz. CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses. OncoImmunology, 5(4):e1113367, 2015.
Cheng Kin, Siew Cheng Wong, Yeh Ching Linn, Liam Pock Ho, Wee Joo Chng and Herbert Schwarz. CD137 Ligand Signalling Induces Differentiation of Primary Acute Myeloid Leukemia Cells. British Journal of Haematology, 165(1):134-44, 2014.
Harfuddin Zulkarnain, Shaqireen Kwajah, Adrian Chong Nyi Sim, Paul Anthony MacAry and Herbert Schwarz. CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses. OncoImmunology, 2(12):e26770, 2013.
Tang Qianqiao, Liang Kai Koh, Dongsheng Jiang and Herbert Schwarz. CD137 ligand reverse signaling skews hematopoiesis towards myelopoiesis during aging. Aging, 5(9):643-52, 2013.
Moh Mei Chung, Paolo Alberto Lorenzini, Charles Gullo, Herbert Schwarz. Tumor Necrosis Factor Receptor 1 associates with CD137 ligand and mediates its reverse signaling. FASEB Journal, 27(8):2957-66, 2013.
Tang Qianqiao, Dongsheng Jiang, Sylvie Alonso, Aakansha Pant, Julia M. Martínez Gómez, David Michael Kemeny, Lieping Chen, Herbert Schwarz. CD137 ligand signaling enhances myelopoiesis during infections. European J. of Immunology, 43(6):1555-67, 2013.
Pang Wan Lu, Weng Tong Ho, and Herbert Schwarz. Ectopic CD137 expression facilitates escape of Hodgkin and Reed-Sternberg cells from immune surveillance. OncoImmunology, 2:4, e23441, 2013.
Ho Weng Tong, Wan Lu Pang, Siew Meng Chong, Antonio Castella, Suhail Al-Salam, Teng Ee Tan, Moh Mei Chung, Koh Liang Kai, Gan Shu Uin, Cheng Cheong Kin and Herbert Schwarz. Expression of CD137 on Hodgkin and Reed-Sternberg Cells Inhibits T cell Activation by Eliminating CD137 Ligand Expression. Cancer Research, 73(2):652-61, 2013.