John Chua

Dr. rer. nat.
Assistant Professor, Department of Physiology
Centre for Life Sciences
National University of Singapore
28 Medical Drive, #04-05 Singapore 117456
Tel: (65) 6516 6824
Email: phsjcje@nus.edu.sg

                                            

Major Research Interests

  • Elucidation of axonal transport mechanisms and their roles in neuronal development and synaptic function.
  • Axonal transport in aging and neurodegeneration.
  • Molecular organization of synaptic macromolecular complexes.

Recent Publications

Butkevich E, Härtig W, Nikolov M, Erck C, Grosche J, Urlaub H, Schmidt CF, Klopfenstein DR, Chua JJ. (2016) Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. Sci Rep. 6:26965.

Kohansal-Nodehi M, Chua JJ, Urlaub H, Jahn R, Czernik D. (2016) Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis. Elife. 5, doi:10.7554/eLife.14530.

Yagensky O, Kalantary Dehaghi T, Chua JJ. (2016) The Roles of Microtubule-Based Transport at Presynaptic Nerve Terminals. Front. Synaptic Neurosci. 8:3. doi: 10.3389/fnsyn.2016.00003.

Binotti B, Pavlos NJ, Riedel D, Wenzel D, Vorbrüggen G, Schalk AM, Kühnel K, Boyken J, Erck C, Martens H, Chua JJ*, Jahn R*. (2015) The GTPase Rab26 links synaptic vesicles to the autophagy pathway. Elife. 4:e05597.

Chua JJ. (2014) Macromolecular complexes at active zones: integrated nano-machineries for neurotransmitter release. Cell Mol Life Sci. 71: 3903-16.

Behrens C, Binotti B, Schmidt C, Robinson CV, Chua JJ, Kühnel K. (2013) Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. PLoS One. 8: e76355.

Boyken J, Grønborg M, Riedel D, Urlaub H, Jahn R, Chua JJ. (2013) Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Neuron. 78: 285-297.

Chua JJ, Schob C, Rehbein M, Gkogkas CG, Richter D, Kindler S. (2012) Synthesis of two distinct SAPAP3 isoforms from a single mRNA is mediated via an upstream open reading frame and alternative translational initiation. Sci. Rep. 2, 484; DOI:10.1038/ srep00484.

Chua JJ, Butkevich E, Worseck JM, Kittelmann M, Grønborg M, Behrmann E, Stelzl U, Pavlos NJ, Lalowski M, Eimer S, Wanker EE, Klopfenstein D, Jahn R. (2012) Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proc Natl Acad Sci U S A. 109: 5862- 5867.