Soong Tuck Wah

Head and Professor, Department of Physiology
Senior Faculty, NUS Graduate School for Engineering and Integrative Sciences
Centre for Life Science
National University of Singapore
28 Medical Drive, #04-44 Singapore 117456
Tel : (65) 6516 1938
Other affiliations: Distinguished Visiting Scientist, National Neuroscience Institute


Major Research Interests

  • Investigations into diversification of calcium channel function via alternative splicing and RNA editing and their implications in neurological and cardiovascular disorders
  • Investigations into physiological significance of alternative splicing and RNA editing of CaV channels in knock-out mice
  • Determination of the role of iron and manganese in Parkinson’s Disease and in neurotoxicity

Recent Publications

Ryan DP, Dias da Silva MR, Soong TW, Fontaine B, Donaldson MR, Kung AW, Jongjaroenprasert W, Liang MC, Khoo DH, Cheah JS, Ho SC, Bernstein HS, Maciel RM, Brown RH and Ptacek L. Mutations in a novel potassium channel (Kir2.6) causes susceptibility to thyrotoxic hypokalemic periodic paralysis. Cell, 2010 Jan 8; 140(1):88-98

Chew KC, Ang ET, Tai YK, Tsang F, Lo SQ, Ong E, Ong WY, Shen HM, Lim KL, Dawson VL, Dawson TM, Soong TW. Enhanced Autophagy from Chronic Toxicity of Iron and Mutant A53T {alpha}-Synuclein: IMPLICATIONS FOR NEURONAL CELL DEATH IN PARKINSON DISEASE. J Biol Chem. 2011 Sep 23;286(38):33380-9

Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction. Circ Res. 2011 Nov 11;109(11):1250-8

Tan BZ, Jiang F, Tan MY, Yu D, Huang H, Shen Y, Soong TW. Functional characterization of alternative splicing in the C-terminus of L-type CaV1.3 channels. J Biol Chem. 2011 Dec 9;286(49):42725-35. [Epub ahead of print]

Tan GM, Yu D, Wang J and Soong TW. Alternative Splicing at C-terminus of CaV1.4 Calcium Channel Modulates Calcium-Dependent Inactivation, Activation Potential and Current Density. J Biol Chem; 2012 Jan 6;287(2):832-47

H Huang, BZ Tan, Y Shen, J Tao, F Jiang, YY Sung, CK Ng, M Raida, G, Köhr, M Higuchi H Fatemi-Shariatpanahi, DT Yue and TW Soong . RNA editing of the IQ domain in Cav1.3 channels modulates their Ca2+-dependent inactivation. Neuron, 2012 Jan 26;73(2):304-16

Gan S-W, Tan E, Lin X, Yu D, Wang J, Tan GM, Vararattanavech A, Yeo CY, Soon CH, Soong TW, Pervushin K and Torres J. The Small Hydrophobic Protein Of The Human Respiratory Syncytial Virus Forms Pentameric Ion Channels. J Biol Chem; 2012 Jul 13;287(29):24671-89. Epub 2012 May 23

Navakkode S, Sajikumar S, Korte M and Soong TW. Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage dependent calcium channels. Learn Mem., 2012 Jun 20;19(7):294-9

Papanayotou C, Almeida ID, Liao P, Oliveira NA, Lu SQ, Kougioumtzidou, E, Zhu L, Shaw A, Sheng G, Streit A, Yu D, Soong TW and Stern CD Calfacilitin: a novel calcium channel modulator essential for initiation of neural plate development Nature Commun, 4, 1837, 14 May 2013

Bazzazi H, Johny MB, Adams PJ, Soong TW and Yue DT Continuosly tunable Ca2+ regulation of RNA-edited CaV1.3 channels Cell Reports, 2013, Oct 31; 5:1-11. doi:10.1016/j.cell.rep2013.09.006

Huang H, Ng CY, Yu D, Zhai J, Lam Y and Soong TW Modest CaV1.342-selective inhibition by compound 8 is a subunit dependent Nature Commun, 2014, Jul 24; 5:4481 (Faculty 1000/ Prime)