James Goh

Professor and Head
Department of Bioengineering, Faculty of Engineering
Research Professor
Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine
Department of Bioengineering, Faculty of Engineering
Block EA, #03-12, 9 Engineering Drive 1, Singapore 117576
Tel: 6516 1911
Email: biegohj@nus.edu.sg
Website : http://www.bioeng.nus.edu.sg/people/PI/James/default.html

Qualifications

  • B.Sc (1st Class) in Mechanical Engineering, University of Strathclyde, Glasgow, United Kingdom 1978
  • PhD in Bioengineering , University of Strathclyde, Glasgow, United Kingdom 1982
  • Chartered Engineer , The Engineering Council, United Kingdom 1993
  • Certificate in Advanced Management Program, NUS Business School 2012

Major Research Interests

  • Tissue Engineering
  • Musculoskeletal Biomechanics
  • Orthopaedic Implants and Devices Design and Development
  • Cardiac Tissue Patch
  • 3D Printing

Selected Research Project

  • Tri-phasic silk/stem cell-based bone-ligament-bone construct in the repair of medial collateral ligament in rabbits
  • Development of a fundamental tissue-engineered bone-ligament-bone graft with novel fixation device to bone tunnels for ACL reconstruction
  • Functionalization of bioresorbable poly epsilon caprolactone 20% tricalcium phosphate cage devices to enhance delivery of biological factors in interbody spine fusion.
  • A novel hybrid bioscaffold for spinal fusion.
  • Silk Sleeve Device for Improving the Graft Bonding at the Bone Tunnel
  • Development of Novel Yolk-Shell Nanoparticle Based Moldable Putty for Surgery
  • Tissue Engineering of the Intervertebral Disc (IVD) – Regenerating the Annulus Fibrosus (AF) with Electrospinning and Physiologically Mimetic Culture
  • Development of cells and bioactive molecules discharging technology for cardiac tissue repair
  • Dimensional control of 3D-printable silk-based structures through physical cues

Selected Publications

Neo, P. Y., Teh, T. K. H., Tay, A. S. R., Asuncion, M. C. T., Png, S. N., Toh, S. L., & Goh, J. C. H. (2016). Stem cell-derived cell-sheets for connective tissue engineering. Connective tissue research, 1-15.

Asuncion, M. C. T., Goh, J. C. H., & Toh, S. L. (2016). Anisotropic silk fibroin/gelatin scaffolds from unidirectional freezing. Materials Science and Engineering: C, 67, 646-656.

Teh, T. K. H., Shi, P., Ren, X., Hui, J. H. P., Tan, W. L. B., Li, J., & Goh, J. C. H. (2016). Augmentation of tendon graft anterior cruciate ligament reconstruction outcome using a silk based osteoconductive sheath. Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 6, 70.

Kok Hiong Teh, T., Cho Hong Goh, J., & Lok Toh, S. (2015). Controlled bioactive molecules delivery strategies for tendon and ligament tissue engineering using polymeric nanofibers. Current pharmaceutical design, 21(15), 1991-2005.

Asuncion, M. T., Goh, J., & Toh, S. (2015). The Cardiac Regeneration Potential of an Anisotropic Silk Fibroin/Gelatin Scaffold in Combination with Chemically-induced Porcine Mesenchymal Stem Cells. Tissue Engineering Part A, Vol. 21, pp. S335-S335.

Shi, P. (2014). Characterization and mechanical performance study of silk/PVA cryogels: towards nucleus pulposus tissue engineering. Biomedical Materials, 9(6), 065002.

Neo PY, Tan DJ, Shi P, Toh SL, Goh J. Enhancing Analysis of Cells and Proteins by Fluorescence Imaging on Silk-Based Biomaterials: Modulating the Autofluorescence of Silk. Tissue engineering Part C, Methods. 2014.

Wang H, Liu XY, Chuah YJ, Goh JC, Li JL, Xu H. Design and engineering of silk fibroin scaffolds with biomimetic hierarchical structures. Chemical communications (Cambridge, England). 2013;49:1431-3.

Shi P, Abbah SA, Saran K, Zhang Y, Li J, Wong HK, et al. Silk fibroin-based complex particles with bioactive encrustation for bone morphogenetic protein 2 delivery. Biomacromolecules. 2013;14:4465-74.

Neo PY, See EY, Toh SL, Goh JC. Temporal profiling of the growth and multi-lineage potentiality of adipose tissue-derived mesenchymal stem cells cell-sheets. Journal of tissue engineering and regenerative medicine. 2013.

Chen K, Ng KS, Ravi S, Goh JC, Toh SL. In vitro generation of whole osteochondral constructs using rabbit bone marrow stromal cells, employing a two-chambered co-culture well design. Journal of tissue engineering and regenerative medicine. 2013.

Shi P, Teh TKH, Toh SL, Goh JCH. Variation of the effect of calcium phosphate enhancement of implanted silk fibroin ligament bone integration. Biomaterials. August 2013; 34:5947-57.

Shi P, Chen K, Goh JCH. Efficacy of BMP-2 Delivery from Natural Protein Based Polymeric Particles. Advanced Healthcare Materials. 2013;2(7):934-939.

Teh TK, Toh SL, Goh JC. Aligned fibrous scaffolds for enhanced mechanoresponse and tenogenesis of mesenchymal stem cells. Tissue engineering Part A. June 2013; 19:1360-72.

He P, Sahoo S, Ng KS, Chen K, Toh SL, Goh JC. Enhanced osteoinductivity and osteoconductivity through hydroxyapatite coating of silk-based tissue-engineered ligament scaffold. Journal of biomedical materials research Part A. 2013;101:555-66.

Chen K, Shi P, Teh TK, Toh SL, Goh JC. In vitro generation of a multilayered osteochondral construct with an osteochondral interface using rabbit bone marrow stromal cells and a silk peptide-based scaffold. Journal of tissue engineering and regenerative medicine. Feb 2013.