Senior Research Fellow
NUS Tissue Engineering Program
Life Sciences Institute, National University of SingaporeResearch Professor
Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine
DSO (Kent Ridge) Building
27 Medical Drive #04-01, Singapore 117510
Tel: 6516 5398
- B.Sc. (Honours Class One), 1991, Monash University, Australia
- Ph.D. (Biochemistry), 1996, Monash University, Australia
Cartilage tissue engineering with tissue-derived chondrocytes and adult stem cells. The focus is on (i) investigating the effect and mechanism of the various microenvironmental cues provided by biomimetic materials, (ii) exploring stimulation protocol(s) and device(s) that integrate material-mediated factors, for the induction and promotion of chondrogenic differentiation. One major emphasis is to manipulate stem cell differentiation to yield chondrocytes of specific zonal characteristic for the recapitulation of the zonal complexity of the cartilage tissue and regeneration of functional cartilage.
Selected Research Project
- Control of mesenchymal stem cell chondrogenic differentiation by the manipulation of microenvironmental cues
- Contribution of physical stimulation to stem cell chondrogenesis
- Study of scaffold microstructural influence on chondrocytes vs MSC chondrogenic differentiation
- Application of biophysically sorted chondrocytes in articular cartilage regeneration
Wu Y, Yang Z*, Law JB, He AY, Abbas AA, Denslin V, Kamarul T, Hui JH, Lee EH*. The combined effect of substrate stiffness and surface topography on chondrogenic differentiation of mesenchymal stem cells. Tissue Eng Part A. 2017 Jan;23(1-2):43-54.
Raghothaman D, Leong MF, Lim TC, Wan AC, Ser Z, Lee EH*, Yang Z*. Cell type dependent morphological adaptation in polyelectrolyte hydrogels governs chondrogenic fate. Biomed Mater. 2016 Apr 4;11(2):025013.
Zhang T, Wen F, Wu Y, Goh GS, Ge Z, Tan LP, Hui JH*, Yang Z*. Cross-talk between TGF-beta/SMAD and integrin signaling pathways in regulating hypertrophy of mesenchymal stem cell chondrogenesis under deferral dynamic compression. Biomaterials. 2015 Jan;38:72-85.
Wu YN, Law JB, He AY, Low HY, Hui JH, Lim CT, Yang Z*, Lee EH*. Substrate topography determines the fate of chondrogenesis from human mesenchymal stem cells resulting in specific cartilage phenotype formation. Nanomedicine (NBM). 2014 Oct;10(7):1507-16.
Raghothaman D, Leong MF, Lim TC, Toh JK, Wan AC Yang Z*, Lee EH*. Engineering cell matrix interactions in assembled polyelectrolyte fiber hydrogels for mesenchymal stem cell chondrogenesis. Biomaterials. 2014 Mar;35(9):2607-16.