Sajikumar Sreedharan

Assistant Professor
Department of Physiology
National University of Singapore
Centre for Life Sciences (CeLS)
Level 4, #04-03, Neurobiology Programme
28 Medical Drive
Singapore 117456
Tel: (65)65165886


Major Research Interests

  • Neural basis of long-term memory (LTM).
  • Synaptic tagging and capture (STC) as an elementary mechanism for storing LTM in neural networks.
  • Metaplasticity as a compensatory mechanism for improving memory in neural networks.

Recent Publications

Sajikumar S (2015) Synaptic Tagging and Capture: From Synapses to Behavior. Editor. SPRINGER, New York. ISBN: 978-1-4939-1760-0 (Print) 978-1-4939-1761-7 (Online)

Sharma M, Sajikumar S (2014), Metaplasticity of Synaptic Tagging and Capture: Memory Beyond the Circle, Synaptic Tagging and Capture Book, SPRINGER, New York. 197-213

Sajikumar S, Morris RG, Korte M (2014). Competition between recently potentiated synaptic inputs reveals a winner-take-all phase of synaptic tagging and capture. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12217-21. doi: 10.1073/pnas.1403643111. Epub 2014 Aug 4.

Li Q, Rothkegal M, Xiao ZC, Abraham WC, Korte M & Sajikumar. S (2012). Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms. Cerebral Cortex. Oct 2012. doi: 10.1093/cercor/bhs315

Sajikumar S, Korte M (2011). Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and capture. Learning & Memory. 2011 Apr 21;18(5):327-331. Print 2011

Sajikumar S, Korte M (2011). Metaplasticity governs compartmentalization of synaptic tagging and capture through BDNF and PKMzeta (PKMĪ¶). Proc Natl Acad Sci U S A. 2011 Jan 19.

Sajikumar S*, Li Q, Abraham WC, Xiao ZC. (2009). Priming of short-term potentiation and synaptic tagging/capture mechanisms mediated by ryanodine receptor activation in rat hippocampal CA1. Learning & Memory. 2009 Feb 17;16(3):178-86.)

Sajikumar S, Navakkode S, Frey JU (2007) Distinct single but not necessarily repeated tetanization is required to induce hippocampal late-LTP in the CA1. Learning & Memory Jan 28;15(2):46-9.

Sajikumar S, Navakkode S, Korz V, and Frey JU (2007). Cognitive and emotional information processing: protein synthesis versus gene expression. Journal of Physiology, Oct 15; 584 (Pt 2):389-400. Epub 2007 Aug 16.

Sajikumar S, Navakkode S, Frey JU (2007) Identification of compartment- and process-specific molecules required for ‘synaptic tagging’ during LTP and LTD in hippocampal CA1. J Neurosci. 2007 May 9; 27(19):5068-80.

Navakkode S, Sajikumar S and Frey JU (2005) MAPK-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging. J Neurosci. 2005 Nov 16;25(46):10664-70.

Navakkode S, Sajikumar S and Frey JU (2004) The type IV-specific phosphodiesterase inhibitor, rolipram, and its effect on hippocampal long-term potentiation and synaptic tagging. J Neurosci. 24 (35): 7740-7744.

Sajikumar S, Navakkode S, Sacktor TC and Frey JU (2005) Synaptic tagging and cross- tagging: the role of protein kinase M zeta in maintaining long-term potentiation, but not long-term depression. J Neurosci. 2005 Jun 29;25 (26).