Programme Leader

 

Barry Halliwell
D. Phil. (Oxford), D. Sc. (London)
Chairman, Biomedical Research Council, Agency for Science, Technology & Research (A*STAR)
Professor, Department of Biochemistry, Tan Chin Tuan Centennial Professor
Senior Advisor, Academic Appointments and Research Excellence,
Office of the Senior Deputy President and Provost
Programme Leader, Neurobiology Research Programme
National University of Singapore
Centre for Life Sciences, 28 Medical Drive #05-01B
Tel: +65 6516 3247
Email: bchbh@nus.edu.sg
Website: https://bch.nus.edu.sg/bchbh.htm

Major Research Interests

Understanding the molecular mechanisms of cell injury and death in human disease and in response to toxins. Antioxidants in nutrition, health and disease. Natural and synthetic antioxidants as therapeutic agents.

  • Mechanisms of neurodegeneration in humans
  • Elucidation of the role of iron in the development of atherosclerosis
  • Antioxidants and pro-oxidants in the human diet in relation to health and disease
  • Mechanisms of ageing in the nematode Caenorhabditis elegans and in human populations

Recent Publications

  1. Butterfield DA and Halliwell B. (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nature Reviews Neuroscience 20, 148-160.
  2. Tang RMY, Cheah IKM, Yew TSK, Halliwell B. (2018) Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues. Sci Rep. 8, 1601.
  3. Cheah IK, Tang RM, Yew TS, Lim KH, Halliwell B. (2017) Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. Antioxid Redox Signal 26, 193-206
  4. Cheah IK, Feng L, Tang RM, Lim KH, Halliwell B. (2016) Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? Biochem Biophys Res Commun. 478, 162-7.
  5. Halliwell B & Gutteridge JMC (2015) Free Radicals in Biology and Medicine. Clarendon Press, Oxford (5th edition), UK
  6. Fong S, Teo E, Ng LF, Chen CB, Lakshmanan LN, Tsoi SY, Moore PK, Inoue T, Halliwell B, Gruber J. (2016) Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model. Sci Rep. 6, 33781.
  7. Tam ZY, Gruber J, Halliwell B, Gunawan R. (2015) Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations. PLoS Comput Biol., 11(5):e1004183
  8. Lakshmanan LN, Gruber J, Halliwell B, Gunawan R. (2015) Are mutagenic non D-loop direct repeat motifs in mitochondrial DNA under a negative selection pressure? Nucleic Acids Res. 43, 4098-108
  9. Gruber J, Chen CB, Fong S, Ng LF, Teo E, Halliwell B. (2015) Caenorhabditis elegans, what we can and cannot learn from ageing worms? Antioxid. Redox Signal. 23, 256-79.
  10. Halliwell B. (2014) Cell culture, oxidative stress, and antioxidants: avoiding pitfalls. Biomed. J. 37, 99-105.
  11. Ng LF, Gruber J, Cheah I, Kiat Goo C, Fun Cheong W, Shui G, Ping Sit K, Wenk MR, Halliwell B. (2014) The mitochondria-targeted antioxidant, MitoQ extends lifespan and improves healthspan of a transgenic C. elegans models of Alzheimer disease. Free Radic Biol Med. 71, 390-401
  12. Seet RC, Lim EC, Tan JJ, Quek A, Chow A, Chong WL, Ng M, Ong CN, Halliwell B. (2014) Does High-Dose Coenzyme Q10 Improve Oxidative Damage and Clinical Outcomes in Parkinson’s Disease? Antioxid Redox Signal. 21, 211-217