Amaury Cazenave Gassiot
Research Assistant Professor, Department of Biochemistry
Yong Loo Lin School of Medicine
Tel: +65 6516 8174
My main research interest is mass spectrometry-based lipidomics. Our team develops methods for qualitative and quantitative analysis of complex lipid profiles as a readout of biochemical processes.
The field of mass spectrometry-based lipidomics has now reach a point where translation to clinical applications is around the corner. In this context, we must strive to 1) educate the community as to what lipidomics can and cannot to, 2) develop ever better analytics, and 3) establish widely accepted guidelines for validation and reproducibility.
After working for many years in all types of model organisms, we now work more and more with clinicians, in view of translating our findings into applications of societal and economic value. Meanwhile we will continue to support basic research in lipidomics.
We have a strong expertise in targeted quantitative analysis of various classes of lipids (glycerolipids, phosphoglycerolipids, sphingolipids, fatty acids, sterols and derivatives) in a variety of tissues (plants, bacteria, yeast, animal models, and human).
1. B. Burla, M. Arita, M. Arita, A.K. Bendt, A. Cazenave-Gassiot, E.A. Dennis, K. Ekroos, X.L. Han, K. Ikeda, G. Liebisch, M.K. Lin, T.P. Loh, P.J. Meikle, M. Orešič, O. Quehenberger, A. Shevchenko, F. Torta, M.J.O. Wakelam, C.E. Wheelock and M.R. Wenk.
MS-based lipidomics of human blood plasma – a community-initiated position paper to develop accepted guidelines. Journal of Lipid Research, 2018, 59(10), 2001-2017.
2. J.P. Chan, B.H. Wong, C.F. Chin, D.L.A. Galam, J.C. Foo, L.C. Wong, S. Ghosh, M.R. Wenk, A. Cazenave-Gassiot, D.L. Silver. The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain. PLoS Biology, 2018, 16(8), e2006443.
3. F. Maixner, D. Turaev, A. Cazenave-Gassiot, M. Janko, B. Krause-Kyora, M.R. Hoopmann, U. Kusebauch, M. Sartain, G. Guerriero, N. O’Sullivan, M. Teasdale, G. Cipollini, A. Paladin, V. Mattiangeli, M. Samadelli, U. Tecchiati, A. Putzer, M. Palazoglu, J. Meissen, S. Lösch, P. Rausch, J.F. Baines, B.J. Kim, H.J. An, P. Gostner, E. Egarter-Vigl, P. Malfertheiner, A. Keller, R.W. Stark, M. Wenk, D. Bishop, D.G. Bradley, O. Fiehn, L. Engstrand, R.L. Moritz, P. Doble, A. Franke, A. Nebel, K. Oeggl, T. Rattei, R. Grimm, A. Zink. The Iceman’s Last Meal Consisted of Fat, Wild Meat, and Cereals. Current Biology, 2018, 28(14), 2348-2355.e9
4. J.A. Bowden, A. Heckert, C.Z. Ulmer, C.M. Jones, J.P. Koelmel, L. Abdullah, L. Ahonen, Y. Alnouti, A. Armando, J.M. Asara, T. Bamba, J.R. Barr, J. Bergquist, C.H. Borchers, J. Brandsma, .B. Breitkopf, T. Cajka, A. Cazenave-Gassiot, A. Checa, M.A. Cinel, R.A. Colas, S. Cremers, E.A. Dennis, J.E. Evans, A. Fauland, O. Fiehn, M.S. Gardner, T.J. Garrett, K.H. Gotlinger, J. Han, Y. Huang, A.H. Neo, T. Hyotylainen, Y. Izumi, H. Jiang, H. Jiang, J. Jiang, M. Kachman, R. Kiyonami, K. Klavins, C. Klose, H.C. Kofeler, J. Kolmert, T. Koal, G. Koster, Z. Kuklenyik, I.J. Kurland, M. Leadley, K. Lin, K.R. Maddipati, D. McDougall, P.J. Meikle, N.A. Mellett, C. Monnin, M.A. Moseley, R. Nandakumar, M. Oresic, R.E. Patterson, D. Peake, J.S. Pierce, M. Post, A.D. Postle, R. Pugh, Y. Qui, O. Quehenberger, P. Ramrup, J. Rees, B. Rembiesa, D. Reynaud, M.R. Roth, S. Sales, K. Schuhmann, M.L. Schwartzman, C.N. Serhan, A. Shevchenko, S.E. Somerville, L. St. John-Williams, M.A. Surma, H. Takeda, R. Thakare, J.W. Thompson, F. Torta, A. Triebl, M. Trotzmuller, S.J.K. Ubhayasekera, D. Vuckovic, J.M. Weir, R. Welti, M.R. Wenk, C.E. Wheelock, L. Yao, M. Yuan, X.H. Zhao, S. Zhou. Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950 Metabolites in Frozen Human Plasma. Journal of Lipid Research, 2017, 58(12), 2275-2288.