Nguyen Nam Long
Assistant Professor, Department of Biochemistry
Yong Loo Lin School of Medicine
Lipids play vital roles in health and diseases. My laboratory is interested in identifying the novel lipid transporters and characterizing their physiological functions. We contributed in the identification of physiological ligands for Mfsd2a and Mfsd2b lipid transporters.
The research that my laboratory carries is innovative in the way that we focus on revealing the molecular and physiological functions of previously uncharacterized proteins.
We will continue to search for novel lipid transporters and unravel the physiological roles of plasma lipids, especially lysolipids, in normal and disease conditions.
We focus our studies on the characterizing the physiological functions of lipid transporters. Our strong expertise includes lipid biochemistry and animal physiology.
1. Vu TM, Ishuzu AN, Foo JC, Toh XR, Zhang F, Whee DM, Torta F, Cazenave-Gassiot A, Matsumura T, Kim S, Shiow STE, Suda T, Silver DL, Wenk MR, Nguyen LN. (2017). Mfsd2b is essential for sphingosine-1-phosphate export in erythrocytes and platelets. Nature 550, 524.
2. Alicia Guemez-Gamboa, Long N. Nguyen, Hongbo Yang, Maha S. Zaki, Majdi Kara, Tawfeg Ben-Omran, Naiara Akizu, Rasim Ozgur Rosti, Basak Rosti, Eric Scott, Jana Schroth, Brett Copeland, , Amaury Cazenave-Gassiot, Debra Quek, Bernice Wong, Markus R. Wenk, Murat Gunel, Stacey Gabriel, Neil Chi, David L. Silver, Joseph G. Gleeson. Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Result in Lethal Microcephaly Syndrome. Nature genetics, 2015. 47(7): p. 809.
3. Long N. Nguyen, Dongliang Ma, Guanghou Shui, Peiyan Wong, Amaury Cazenave Gassiot, Xiaodong Zhang, Markus R. Wenk, Eyleen L.K. Goh, and David L. Silver. (2014). Mfsd2a is a transporter for the essential omega-3 fatty acid DHA. Nature, 2014. 509 (7501): p. 503.